TABLE 1.

Effects of cannabinoids on nicotinic acetylcholine receptors.

Cannabinoid tested	Effect and conclusion	References
CBD	Decrease of the amplitudes of miniature end-plate potentials in frog neuromuscular junction	Turkanis and Karler, (1986)
AEA	Inhibition of α7 nACh receptors with IC50 of 229 nM in Xenopus oocytes	Oz et al. (2003)
2-AG	Inhibition of α7 nACh receptors with IC50 of 168 nM in Xenopus oocytes	Oz et al. (2004b)
CP55940	Inhibited α7-nACh receptors with an IC50 value of 2.7 µM in Xenopus oocytes	Oz et al. (2004b)
AEA	In the concentration range of 200 nM to 2 μM, reduced the maximal amplitudes and increased the desensitization of human α4β2 nACh receptors expressed in SH-EP1 cells	Spivak et al. (2007)
Methanandamide	Methanandamide (3 μmol/kg) produced an AM 251-insensitive inhibition of the nicotine-induced tachycardia	Baranowska et al. (2008)
AEA	Inhibited ACh-induced 86Rb+ effluxes with an IC50 of 0.9 µM in rat thalamic synaptosomes	Butt et al. (2008)
WIN55,212-2	Inhibited native nicotinic receptor with an IC50 value about 3 µM in cultured rat trigeminal ganglion neurons	Lu et al. (2011)
CBD	Inhibits human α7-nACh receptor with an IC50 of 11.3 µM in Xenopus oocytes and rat hippocampal interneurons	Mahgoub et al. (2013)