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. 2022 Sep 1;28(12):2172–2182. doi: 10.1111/cns.13959

TABLE 2.

Characteristics of the selected features in the “multimodal,” “Function,” “Diffusion,” “Volumetry,” “Iron” models

Model Features IPD MSA‐P Adjusted‐p
Multimodal mALFF: left dorsolateral putamen 0.71 ± 0.12 0.43 ± 0.18 <0.001***
outFC: left dorsolateral putamen‐right A4 upper limber region of precentral gyrus 0.38 ± 0.17 0.21 ± 0.13 <0.001***
MD (×100): left dorsolateral putamen 0.08 ± 0.01 0.09 ± 0.02 <0.001***
outFC: left dorsolateral putamen‐right cerebellum IV 0.26 ± 0.15 0.16 ± 0.12 <0.001***
inFC: left dorsal caudate‐right nucleus accumbens 0.41 ± 0.17 0.29 ± 0.14 <0.001***
Iron GLCM‐DifferenceEntropy: left dorsolateral putamen 1.23 ± 0.20 1.43 ± 0.29 <0.001***
Iron Entropy: left dorsolateral putamen 1.96 ± 0.38 2.30 ± 0.48 <0.001***
outFC: left dorsal caudate‐right A9 lateral region of superior frontal gyrus 0.47 ± 0.19 0.36 ± 0.20 <0.001***
outFC: left dorsolateral putamen‐right A6 medial area of superior frontal gyrus 0.28 ± 0.16 0.18 ± 0.15 0.002**
outFC: left dorsal caudate ‐right cerebellum IV 0.34 ± 0.17 0.24 ± 0.21 0.009**
Iron GLRLM‐GLRLM‐RunLengthNonUniformityNormalized: left dorsolateral putamen 0.38 ± 0.07 0.43 ± 0.07 0.002**
OutFC: left dorsolateral putamen‐right cerebellum V 0.32 ± 0.17 0.21 ± 0.17 0.012*
OutFC: left dorsal caudate‐right A9/46 dorsal area of middle frontal gyrus 0.34 ± 0.19 0.24 ± 0.16 0.005**
OutFC: right ventromedial putamen‐left A10 lateral area of middle frontal gyrus 0.32 ± 0.12 0.26 ± 0.13 0.003**
OutFC: right dorsolateral putamen‐left A6medial area of superior frontal gyrus 0.27 ± 0.17 0.19 ± 0.12 0.011*
Volumetry (×100): left dorsolateral putamen 0.20 ± 0.02 0.20 ± 0.03 0.018*
Function mALFF: left dorsolateral putamen 0.71 ± 0.12 0.43 ± 0.18 <0.001***
OutFC: left dorsolateral putamen‐right A4 upper limber region of precentral gyrus 0.38 ± 0.17 0.21 ± 0.13 <0.001***
OutFC: left dorsolateral putamen‐right cerebellum IV 0.26 ± 0.15 0.16 ± 0.12 0.001***
InFC: left dorsal caudate‐right nucleus accumbens 0.41 ± 0.17 0.29 ± 0.14 <0.001***
outFC: left dorsal caudate‐right A9 lateral region of superior frontal gyrus 0.47 ± 0.19 0.37 ± 0.20 0.010*
outFC: left dorsolateral putamen‐right A6medial area of superior frontal gyrus 0.28 ± 0.16 0.18 ± 0.148 0.002**
outFC: left dorsal caudate ‐right cerebellum IV 0.34 ± 0.17 0.24 ± 0.21 0.010*
outFC: left dorsolateral putamen‐right cerebellum V 0.32 ± 0.17 0.21 ± 0.17 0.005**
outFC: left dorsal caudate‐right A9/46dorsal area of middle frontal gyrus 0.34 ± 0.19 0.24 ± 0.16 0.007**
outFC: right ventromedial putamen‐left A10lateral area of middle frontal gyrus 0.32 ± 0.12 0.26 ± 0.13 0.010*
outFC: right dorsolateral putamen‐left A6medial area of superior frontal gyrus 0.27 ± 0.17 0.19 ± 0.12 0.010*
outFC: left dorsolateral putamen‐left lateral prefrontal thalamus 0.36 ± 0.18 0.27 ± 0.18 0.010*
Diffusion MD (×100): left dorsolateral putamen 0.08 ± 0.01 0.09 ± 0.02 <0.001***
FA: left dorsal caudate 0.25 ± 0.03 0.23 ± 0.03 0.012*
Volumetry Volume (×100): left dorsolateral putamen 0.20 ± 0.02 0.20 ± 0.03 0.007**
Volume (×100): right dorsolateral putamen 0.20 ± 0.02 0.20 ± 0.03 0.013*
Iron Entropy: left dorsolateral putamen 1.96 ± 0.38 2.30 ± 0.48 <0.001***
DifferenceEntropy: left dorsolateral putamen 1.23 ± 0.20 1.43 ± 0.29 <0.001***
GLRLRunLengthNonUniformityNormalized: left dorsolateral putamen 0.38 ± 0.07 0.43 ± 0.07 0.001**
GLSZM‐SizeZoneNonUniformityNormalized: left dorsolateral putamen 0.24 ± 0.04 0.27 ± 0.05 0.009**

Note: Values expressed as mean ± SD.

Abbreviations: FA, fractional aniotrophy; GLCM, gray level co‐occurrence matrix; GLRLM, gray level run length matrix; GLSZM, gray level size zone matrix; IPD, idiopathic Parkinson's disease; MD, mean diffusivity; MSA‐P, parkinsonian variant of multiple system atrophy.

*Statistical significance, p < 0.05; **statistical significance, p < 0.01; ***statistical significance, p < 0.001.