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. 2022 Oct 2;28(12):2319–2330. doi: 10.1111/cns.13981

FIGURE 6.

FIGURE 6

Inhibition of RIP2/NF‐κB can inhibit RIP2‐overexpressing glioma xenografts resistant to TMZ. (A) Qualified normal U251 cells and vector‐transfected U251 cell tumor‐bearing mice were treated with TMZ for 25 days. Xenograft tumors were excised and photographed. Changes in tumor volume of tumor‐bearing mice in control, vector, control+TMZ, and vector+TMZ groups from one to 25 days. ** P < 0.01. (C, F) Xenograft tumor weights in each group at 25 days. **P < 0.01. (D) Qualified U251 cell tumor‐bearing mice transfected with RIP2 plasmid were treated with TMZ, SC75741 + TMZ, and GSK583 + TMZ for 25 days. Xenograft tumors were excised and photographed. (E) Changes in tumor volume of tumor‐bearing mice in control, TMZ, SC75741 + TMZ, and GSK583 + TMZ groups from one to 25 days. **P < 0.01. (G, H) Changes in relative tumor proliferation rate (T/C) of xenograft tumors in each group.