FIGURE 1.

5‐FU administration promotes sensorimotor functional recovery and reduces the scar formation after SCI. (A) Percentage of hind limb errors in the horizontal ladder test after SCI (n = 6/group). (B) BBB scores of SCI rats with different approaches (n = 6/group). (C–D) Statistical results of thermal and paw withdrawal thresholds in SCI rats after different treatments (n = 6/group). (E) Body weight of SCI rats with different approaches at 7‐, 14‐, 21‐ and 28‐days post‐operation (n = 6/group). (F) Total WBC counts in the blood of 5‐FU treated group at different time points (n = 5/group). (G) Low power photographs of the spinal cord between vehicle and 5‐FU groups. (H) Scar area of the lesion site (n = 6). (I–J) Nissl's staining of the coronal spinal cord in Figure a1 and b1 form Figure G. Nissl body in the cytoplasm of nerve cells (dark blue‐purple, black arrow). * indicates the lesion core. The bottom panels are an enlargement of the box in Figure I/J. (K–L) Nissl's staining of the spinal cross section in the asterisked central plane. Graphical data are presented as the mean ± standard deviation. Scale bar = 1 mm. R: right, L: left, V: ventral, D: dorsal. *p < 0.05, **p < 0.01, ***p < 0.001