TABLE 3.
Challenge immunity in infant CD-1 mice passively immunized with serum from mice actively infected with B. burgdorferi sensu stricto cN40, B. afzelii PKo, B. garinii PBi, or B. burgdorferi sensu lato 25015 and then challenged with homologous or heterologous Borrelia species
| Serum treatmentc | No. of culture-positive micea/no. tested with the following challenge inoculumb:
|
|||
|---|---|---|---|---|
| cN40 | PKo | PBi | 25015 | |
| cN40 | 0/3 | 2/3 | 2/2 | 2/2 |
| PKo | 3/3 | 0/3 | 3/3 | 3/3 |
| PBi | 3/3 | 1/3 | 0/3 | 3/3 |
| 25015 | 2/3 | 2/3 | 2/3 | 0/3 |
| Sham | 1/1 | 3/3 | 3/3 | 3/3 |
Culture results for blood, urinary bladder, and spleen. A mouse was scored positive if any single site was positive.
Mice were challenged with cultured B. burgdorferi cN40, B. afzelii PKo, B. garinii PBi, or B. burgdorferi sensu lato 25015 18 h after passive immunization.
Mice were passively immunized 18 h prior to challenge inoculation with 10 μl of immune serum from mice infected with B. burgdorferi cN40, B. afzelii PKo, B. garinii PBi, or B. burgdorferi sensu lato 25015 or with normal mouse serum (sham).