TABLE 4.
Challenge immunity in adult C3H mice immunized by active infection with B. burgdorferi sensu stricto cN40, B. afzelii PKo, or B. garinii PBi, treated with an antibiotic, and then challenged by transplantation of ear tissue from mice infected with homologous or heterologous Borrelia species
| Immunizing inoculumc | No. of culture-positive micea/no. tested with the following transplant challenge inoculumb:
|
|||
|---|---|---|---|---|
| cN40 | PKo | PBi | Sham | |
| cN40 | 1/5d | 4/4 | 1/5 | 0/5 |
| PKo | 5/5 | 2/5d | 3/5 | 0/5 |
| PBi | 4/5 | 4/4 | 1/5 | 0/5 |
| Sham | 4/5 | 5/5 | 3/5 | 0/5 |
Culture results for blood, urinary bladder, spleen, ear, and inoculation site. A mouse was scored positive if any single site was positive.
Mice were challenged on day 45 by transplantation of ear tissue from donor mice that were actively infected with B. burgdorferi cN40, B. afzelii PKo, or B. garinii PBi or from uninfected mice (sham).
Mice were immunized by active infection following inoculation with cultured B. burgdorferi cN40, B. afzelii PKo, or B. garinii PBi or BSKII medium (sham) and treatment with ceftriaxone on day 30.
Culture positive at site of inoculation (transplant) only.