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(a) A representative snapshot structure of ADPA-IL-6 complex on a gold surface obtained from DMD simulations. (b) Three CDR loops were adopted from a full sequence of anti-IL-6 antibody (PDB ID 4o9h). Two ADPA schemes were designed by connecting three CDR loops with spacers and cystine residues were introduced for site-specific functionalization on gold. (c, d) SPR kinetics of interaction between two ADPA schemes and human IL-6.
