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. 2022 Nov 2;12(11):220203. doi: 10.1098/rsob.220203

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© 2022 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 4. — Suppression of mitotic exit defects by MCK1 deletion. (a) Effect of MCK1 or KIN4 deletion on the growth phenotype of temperature-sensitive MEN mutants at the indicated temperatures. (b) MCK1 or KIN4 deletion rescues the cold sensitive growth defect of lte1Δ cells. Cells carried chromosomal LTE1 deletion and a URA3-based plasmid expressing LTE1 (pRS316-LTE1). Growth in the presence (SC-complete) or absence (5-FOA) of pRS316-LTE1 was analysed after 7 days of incubation at 14°C. (c) Growth of the indicated strains in the presence (SC-complete) or absence (5-FOA) of pRS316-LTE1 was analysed after 3 days at 30°C. (d) Graph shows the percentage of SPOC-deficient phenotypes for the indicated strains. Average ± s.d. of three independent experiments is shown. N = 100 anaphase cells per strain and experiment. Asterisk indicates a significant difference based on the two-tailed Student's t-test, p < 0.05 (*), p < 0.001 (**) and p < 0.0001 (***). (e) Growth of the indicated strains analysed as in (c).