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. 2022 Oct 19;12:965660. doi: 10.3389/fonc.2022.965660

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Copyright © 2022 Zhang, Dong, Wu, Li, Liu, Liu, Gao, Gao, Song, Zheng and Yao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of irradiation on the morphology, molecular markers, and proliferation of CAFs. (A, B) Morphology of CAFs without irradiation (A) and CAFs that received 8Gy irradiation (B) were compared under a light microscope (100×), and both groups of cells were spindle-shaped, but the irradiated cells were slightly disorganized; (C) Representative western blotting for FAP, α-SMA, and vimentin in CAFs that received 0Gy, 8Gy, and 15Gy irradiation; (D) The relative expression differences of the biomarkers after normalization of the GAPDH were analyzed by quantitatively comparing the density differences of the immunoblot bands; (E) MTT experiment was used to analyze the proliferation activity of CAFs under 0Gy, 8Gy, and 15Gy irradiation. T-test, *P < 0.05; (F) The sketch map of supernatants preparations of CAFs. (T-test, data are presented as the mean ± S.D. *P < 0.05, **P < 0.01, ***P < 0.001).