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. 2022 Oct 19;12:965660. doi: 10.3389/fonc.2022.965660

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Copyright © 2022 Zhang, Dong, Wu, Li, Liu, Liu, Gao, Gao, Song, Zheng and Yao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Subcellular structure of CAFs changed after irradiation was seen under transmission electron microscopy. (A–D) The observation of the subcellular structure of CAFs before irradiation showed that the nuclei were oval with obvious nucleoli (▲). Rough endoplasmic reticulum (←), mitochondria (↓), vesicles (◆), microtubules (→), and microfilaments can be seen in the cytoplasm; (E–H) The observation of the subcellular structure of CAFs after 8Gy irradiation revealed double nucleoli and double nuclei (★) and lobulated nuclei in the nucleus. The rough endoplasmic reticulum increased and expanded, and mitochondria were divided and increased, while Golgi apparatus (▼) increased in the cytoplasm.