Table 3.
Association of time-weighted average of risk factor measurements from visit 1 to visit 5 and cardiovascular health status at visit 5. Association expressed as odds ratio (95% confidence interval).
| Healthy (N=1691) | Subclinical Disease (N=2516) | Clinical CVD (N=1498) | |
|---|---|---|---|
| SBP | |||
| Time-weighted average (mmHg) | 120.6±12.37 | 124.5±12.70 | 127.0±13.19 |
| Model 1 | Ref | 1.021 (1.016–1.027) | 1.033 (1.026–1.039) |
| Model 2a | Ref | 1.014 (1.008–1.020) | 1.008 (1.0003–1.015) |
| DBP | |||
| Time-weighted average (mmHg) | 70.3±7.52 | 70.0±7.41 | 70.2±7.85 |
| Model 1 | Ref | 1.012 (1.003–1.021) | 1.006 (0.995–1.016) |
| Model 2a | Ref | 1.001 (0.991–1.011) | 0.977 (0.966–0.989) |
| PP | |||
| Time-weighted average (mmHg) | 50.2±9.19 | 54.6±10.31 | 56.7±11.11 |
| Model 1 | Ref | 1.031 (1.023–1.038) | 1.052 (1.044–1.061) |
| Model 2a | Ref | 1.024 (1.016–1.032) | 1.027 (1.017–1.036) |
| LDL-C | |||
| Time-weighted average (mg/dL) | 120.8±24.68 | 119.8±24.40 | 119.0±25.69 |
| Model 1 | Ref | 0.997 (0.995–0.9998) | 0.996 (0.993–0.999) |
| Model 2b | Ref | 0.997 (0.994–0.9999) | 0.994 (0.991–0.998) |
| TG | |||
| Time-weighted average (mg/dL) | 128.4±58.32 | 129.2±61.69 | 141.7±65.01 |
| Model 1 | Ref | 0.9996 (0.998–1.0008) | 1.003 (1.002–1.005) |
| Model 2b | Ref | 0.999 (0.998–1.000) | 1.000 (0.999–1.002) |
| BMI | |||
| Time-weighted average (kg/m2) | 27.9±4.63 | 27.9±4.90 | 29.1±5.31 |
| Model 1 | Ref | 1.018 (1.004–1.032) | 1.069 (1.053–1.085) |
| Model 2c | Ref | 1.023 (1.008–1.039) | 1.043 (1.025–1.061) |
Model 1 adjusted for visit 5 age, sex, and race.
Model 2 adjusted for model 1 plus visit 5 total cholesterol, HDL cholesterol, diabetes status, smoking status, number of hypertensive medications at visits 1, 2, 3, 4, and 5.
Model 2 adjusted for model 1 plus visit 5 SBP, diabetes status, smoking status, number of lipid-lowering medications at visits 1, 2, 3, 4, and 5.
Model 2 adjusted for model 1 plus visit 5 SBP, total cholesterol, HDL cholesterol, diabetes status, and smoking status.
BMI = body mass index; CVD = cardiovascular disease; DBP = diastolic blood pressure; HDL = high-density lipoprotein; LDL-C = low-density lipoprotein cholesterol; PP = pulse pressure; SBP = systolic blood pressure; TG = triglycerides.