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. 2022 Oct 14;13:1010257. doi: 10.3389/fimmu.2022.1010257

Figure 4.

Figure 4

Treatment of chronically infected mice with anakinra (IL-1R antagonist) improves general health but not systolic function. C57BL/6 mice were infected with the Colombian strain of T. cruzi (100–200 parasites) and at chronic stage (240–270 dpi), treated with anakinra (10–25 mg/kg, i.p., sum of two independent experiments with 100 and 200 parasites/inoculum). (A) Survival curve. (B) Percentage of body weight gain. (C) Serum levels of IL-1β. (D) Less pronounced disease signals such as prostration, bald spots, ruffled fur and hunched back. (E) The relative weight of the heart (heart mg/tibia mm). (F) Echocardiography: ejection fraction (EF), stroke volume (SV), left ventricle diastolic volume (LVDV), right ventricle area (RV), and left ventricle area (LV). Data represent the mean ± SEM from 11 to 15 mice per group. NI, noninfected; Tc, chronically infected mice; Tc+AK, chronically infected mice treated with anakinra.