TABLE 2.

Performance of self-test rapid antigen tests compared with viral culture, subgenomic RNA, and genomic RNA.

	No. of pairs	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)	NPV (95% CI)
RAT vs. viral culture
Overall	138	44% (20–70)	75% (66–82)	18% (8–34)	91% (84–96)
≤5 days	40	83% (36–100)	50% (32–68)	23% (8–45)	94% (73–100)
>5 days	98	20% (3–56)	84% (75–91)	12% (2–38)	90% (82–96)
RAT vs. sgRNA
Overall	138	45% (33–57)	89% (79–95)	79% (63–90)	63% (53–72)
≤5 days	40	81% (58–95)	74% (49–91)	77% (55–92)	78% (52–94)
>5 days	98	28% (16–43)	94% (84–99)	81% (54–96)	60% (48–70)
RAT vs. gRNA
Overall	138	37% (28–47)	100% (90–100)	100% (91–100)	36% (27–46)
≤5 days	40	73% (54–88)	100% (69–100)	100% (85–100)	56% (31–78)
>5 days	98	22% (13–34)	100% (87–100)	100% (79–100)	32% (22–43)

CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value; sgRNA, subgenomic RNA; gRNA, genomic RNA.