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. 2022 Oct 19;13:1017147. doi: 10.3389/fmicb.2022.1017147

Figure 6.

Figure 6

Healthy fecal microbiota attenuated letrozole-induced PCOS. (A) The schedule of this animal experiment; FMTT, the treatment by fecal microbiota transplantation; OGTT, oral glucose tolerance test; and ITT, insulin tolerance test. (B) Body weight change. (C) Menstrual cycle estimation. (D) Ovarian histopathology. (E) Cystic follicle counts. Biochemical parameters include the levels of T (F), E2 (G), LH (H), FSH (I), LH/FSH (J), FBG (K), FSIns (L), HOMA-IR (M), OGTT (N), ITT (O), and CRP (P) in rats; T, testosterone; E2, estradiol; LH, luteinizing hormone; FSH, follicle-stimulating hormone; LH/FSH, the ratio of LH to FSH; FSG, fasting serum glucose; FSIns, fasting serum insulin; HOMA-IR, homeostasis model assessment of insulin resistance (HOMA-IR = FBG × FSIns/22.5); and CRP, C-reactive protein. n = 6 rats in each group. Data are shown as mean ± standard deviation. Difference among four groups is compared by one-way ANOVA followed by Tukey’s post-hoc test. *represents the comparison between control and PCOS model groups (*p < 0.05, **p < 0.01, ***p < 0.001). # stands for the difference between diane-35 treatment and PCOS model groups (#p < 0.05, ##p < 0.01, ###p < 0.001). & indicates the difference between FMTT and PCOS model groups (&p < 0.05, &&p < 0.01, &&&p < 0.001).