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. 2022 Nov 2;18(11):e11006. doi: 10.15252/msb.202211006

Figure 3. Transcriptional signatures associate with metabolic pathways.

Figure 3

  1. Heatmap of P‐value of association between SMPDB core metabolic pathways and progeny defined transcriptional programmes (P represents corrected iterative hypergeometric test P‐value).
  2. log10 (P‐value)*correlation direction against rank order for all SMPDB core metabolic pathways and their association with NRF2, showing glutathione metabolism as a clear outlier.
  3. log10 glutamate levels against NRF2 relative activity. R represents Pearson correlation coefficient.
  4. Network of correlated metabolites and genes across all RNA expression and metabolic data. Metabolites and genes are linked if their expression correlates with a Pearson correlation coefficient > 0.8. Plotted are all strongly connected components with 10 or more members.
  5. Enrichment of metabolites (left – Metaboanalyst) and genes (right – Gprofiler) in cluster 1.
  6. Enrichment of metabolites (left – Metaboanalyst) and genes (right – Gprofiler) in cluster 2.