Fig. 1.

Tackling oncogenic MYC. The MYC transcription factor regulates diverse cellular processes (inner circle) that promote cell growth and proliferation, and are hijacked in cancer cells to fuel tumor aggressiveness and/or therapy resistance. However, the same processes may become a dependency in MYC‐driven cancer, and may thus be exploited for pharmacological intervention (outer circle): drug classes that impact these processes are indicated with their relevant molecular targets.