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Synthetic lethality and viability. (A) a schematic representation of synthetic lethality. A cell can tolerate the loss of gene a or gene B but cannot survive with the loss of both genes. (B) a schematic representation of synthetic viability. A cell cannot survive the loss of gene a. however, the loss of both genes a and B rescues cellular viability. [Colour figure can be viewed at wileyonlinelibrary.com]
