Table 3.
Univariable and Multivariable Cox Hazard Analysis for the Primary Endpoint
| Univariable Analysis |
Multivariable Analysis |
|||
|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Age | 1.02 (1.01-1.04) | 0.011 | 1.01 (0.99-1.03) | 0.28 |
| Female | 1.21 (0.88-1.65) | 0.23 | 0.93 (0.65-1.32) | 0.68 |
| NYHA functional class | 1.30 (0.99-1.69) | 0.060 | 1.03 (0.76-1.41) | 0.83 |
| Hemoglobin | 0.87 (0.80-0.94) | 0.0009 | 0.94 (0.85-1.04) | 0.21 |
| Serum sodium | 1.02 (0.97-1.07) | 0.39 | 1.02 (0.98-1.08) | 0.28 |
| Albumin | 0.56 (0.40-0.78) | 0.0007 | 0.73 (0.48-1.10) | 0.13 |
| Total bilirubin | 1.03 (0.64-1.66) | 0.89 | 1.28 (0.76-2.14) | 0.35 |
| Log NT-proBNP | 2.56 (1.91-3.44) | <0.0001 | 2.31 (1.66-3.23) | <0.0001 |
| Average E/e′ ≥14 or 11 | 1.64 (1.17-2.28) | 0.004 | ||
| TRV ≥2.8 | 1.91 (1.38-2.64) | 0.0001 | ||
| IVCC <50% | 1.65 (1.20-2.27) | 0.002 | ||
| Echocardiographic congestion grade | 1.76 (1.43-2.18) | <0.0001 | 1.51 (1.19-1.92) | 0.0006 |
Multivariable Cox hazard model included clinical variables (age, sex, and NYHA functional class), biomarkers (hemoglobin, serum sodium, albumin, total bilirubin, and NT-proBNP), and echocardiographic congestion grade determined by average E/e′, TRV, and IVCC at discharge.