Table 1.
Patient Baseline Characteristics According to Study Period (2008-2015 and 2016-2020)
| 2008-2015 (n = 316) | 2016-2020 (n = 315) | |
|---|---|---|
| Female | 241 (76.3) | 250 (79.4) |
| Age, y | 47.9 ± 16.7 | 52.7 ± 16.9 |
| Etiology | ||
| IPAH/HPAH | 158 (50.0) | 161 (51.1) |
| CTD-PAH | 78 (24.7) | 102 (32.4) |
| CHD-PAH | 41 (13.0) | 22 (7.0) |
| PoPH | 29 (9.2) | 22 (7.0) |
| Others | 10 (3.2) | 8 (2.5) |
| NYHA functional class | ||
| I | 16 (5.1) | 27 (8.6) |
| II | 124 (39.2) | 151 (47.9) |
| III | 137 (43.4) | 119 (37.8) |
| IV | 39 (12.3) | 18 (5.7) |
| 6MWD, m | 360 ± 123 | 362 ± 128 |
| BNP, ng/L | 213 ± 301 | 139 ± 230 |
| Hemodynamics | ||
| mPAP, mm Hg | 45.4 ± 15.0 | 38.6 ± 13.1 |
| PAWP, mm Hg | 8.5 ± 3.3 | 8.6 ± 3.5 |
| mRAP, mm Hg | 6.2 ± 3.9 | 6.0 ± 3.9 |
| PVR, dyn·s·cm−5 | 894 ± 602 | 622 ± 402 |
| Cardiac index, L/min/m2 | 2.56 ± 1.00 | 2.92 ± 1.02 |
| SvO2, % | 67.6 ± 9.1 | 68.1 ± 9.3 |
Values are n (%) or mean ± SD.
6MWD = 6-minute walk distance; BNP = brain natriuretic peptide; CHD-PAH = congenital heart disease-related pulmonary arterial hypertension; CTD-PAH = connective tissue disease-related pulmonary arterial hypertension; IPAH/HPAH = idiopathic pulmonary arterial hypertension/hereditary pulmonary arterial hypertension; mPAP = mean pulmonary arterial pressure; mRAP = mean right arterial pressure; NYHA = New York Heart Association; PAWP = pulmonary artery wedge pressure; PoPH = portopulmonary hypertension; PVR = pulmonary vascular resistance; SvO2 = mixed venous oxygen saturation.