Table 4.
Unadjusted Clinical Outcomes According to an Additional SB-Opening Procedure for LM or True Bifurcation Lesions
| Event Rates∗ at 5-year |
Unadjusted |
IPTW Adjusted |
||||
|---|---|---|---|---|---|---|
| Simple Crossover | SB Opening | HR† (95% CI) | p Value | HR† (95% CI) | p Value | |
| LM lesion | 489 | 193 | ||||
| Target lesion failure‡ | 37 (9.5) | 19 (11.3) | 1.24 (0.72–2.14) | 0.442 | 0.92 (0.41–2.06) | 0.836 |
| Death from any cause | 33 (8.2) | 7 (4.1) | 0.49 (0.22–1.11) | 0.086 | 0.83 (0.27–2.56) | 0.741 |
| Cardiac | 20 (5.1) | 5 (3.0) | 0.60 (0.23–1.59) | 0.303 | 0.79 (0.19–3.36) | 0.755 |
| Noncardiac | 12 (3.1) | 2 (1.1) | 0.33 (0.08–1.46) | 0.145 | 0.84 (0.13–5.41) | 0.854 |
| MI | 8 (1.9) | 8 (4.7) | 2.27 (0.88–5.88) | 0.092 | 3.62 (1.05–12.44) | 0.041 |
| Target-vessel MI | 6 (1.4) | 5 (3.0) | 1.82 (0.58–5.74) | 0.306 | 2.44 (0.51–11.56) | 0.261 |
| Any revascularization | 43 (11.2) | 25 (15.0) | 1.50 (0.93–2.43) | 0.100 | 1.50 (0.73–3.09) | 0.271 |
| Target lesion | 18 (4.8) | 12 (7.3) | 1.53 (0.75–3.14) | 0.241 | 1.34 (0.47–3.81) | 0.580 |
| Target vessel | 27 (7.1) | 20 (11.9) | 1.87 (1.07–3.28) | 0.029 | 1.30 (0.59–2.89) | 0.519 |
| Definite stent thrombosis | 7 (1.6) | 0 (0) | 0.32 (0.04–2.56) | 0.282 | 1.44 (0.24–8.7) | 0.692 |
| True bifurcation | 1,196 | 316 | ||||
| Target-lesion failure† | 26 (5.3) | 19 (7.8) | 1.29 (0.74–2.26) | 0.362 | 0.93 (0.43–2.01) | 0.854 |
| Death from any cause | 29 (5.8) | 11 (4.4) | 0.74 (0.38–1.43) | 0.372 | 0.68 (0.27–1.76) | 0.432 |
| Cardiac | 16 (3.1) | 9 (3.7) | 1.07 (0.5–2.29) | 0.856 | 1.10 (0.39–3.11) | 0.864 |
| Noncardiac | 13 (2.8) | 2 (0.8) | 0.29 (0.07–1.28) | 0.103 | 0.13 (0.03–0.57) | 0.007 |
| MI | 6 (1.3) | 4 (1.5) | 1.06 (0.32–3.53) | 0.921 | 0.46 (0.14–1.56) | 0.214 |
| Target vessel MI | 3 (0.5) | 3 (1.2) | 1.56 (0.35–6.99) | 0.559 | 0.64 (0.14–2.88) | 0.561 |
| Any revascularization | 41 (8.2) | 23 (9.4) | 0.98 (0.6–1.6) | 0.928 | 0.63 (0.3–1.3) | 0.210 |
| Target lesion | 11 (2.4) | 8 (3.4) | 1.24 (0.52–2.97) | 0.622 | 0.55 (0.22–1.33) | 0.181 |
| Target vessel | 23 (4.8) | 15 (6.3) | 1.17 (0.62–2.19) | 0.632 | 0.58 (0.28–1.19) | 0.140 |
| Definite stent thrombosis | 4 (0.7) | 2 (0.8) | 1.28 (0.3–5.35) | 0.739 | 2.09 (0.37–11.85) | 0.405 |
Values are n or n (%), unless noted otherwise.
∗
Event rates are based on Kaplan-Meier estimates.
†
Hazard ratios are for the SB-opening group compared to the simple crossover group.
‡
Target lesion failure was defined as a composite of death by cardiac causes, target vessel MI, or target lesion revascularization.