Table 1.
Parameters for Risk Stratification of VF Events in BrS
| Brugada et al30 | Eckardt et al31 | Kamakura et al25 | FINGER27 | PRELUDE29 | Takagi et al26 | Kawazoe et al32 | Sieira et al35 | Yamagata and Shimizu39 | Kawada and Morita33,34 | BRUGADA-RISK33 | Rattanawong et al28 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Year | 2002 | 2005 | 2009 | 2010 | 2012 | 2007 | 2016 | 2017 | 2017 | 2018 | 2021 | 2021 |
| N | 334 | 212 | 330 | 1,029 | 308 | 430 | 143 | 400 | 415 | 393 | 1,110 | 3,386 |
| Prior VF | a | a | a | a | a | a | a | a | a | a | ||
| Syncope | a | a | b | a | a | a | a | a | a | a | ||
| Spontaneous type1 | a | a | b | a | a | b | b | a | a | a | ||
| FH of SCD | b | b | a | b | b | b | a | a | aOnly age <40 y | |||
| VF inducibility | a | b | b | b | b | b | b | a | ||||
| Male | b | b | a | b | ||||||||
| SCN5A mutation | a | a | ||||||||||
| Others | Logistic model | Sieira score | Shanghai score | Meta-analysis | ||||||||
| QRS duration in lead V2 >90 ms | Syncope | +Atrial fibrillation | +Early repolarization | |||||||||
| Inferolateral J-wave | +r–J interval in V1 | +Type 1 Brugada ECG pattern | ||||||||||
| Horizontal ST-segment morphology | +QRS duration in V6 | In peripheral leads | ||||||||||
| After J-wave | +Tp-e dispersion |
BRS = Brugada syndrome; BRUGADA RISK =A Primary Prevention Clinical Risk Score Model for Patients With Brugada Syndrome; ECG = electrocardiogram; FH = family history; FINGER = France, Italy, Netherlands Germany registry; PRELUDE = PRogrammed ELectrical stimUlation preDictive Value); SSCD = sudden cardiac death; VF = ventricular fibrillation.
a
Risk factors associated to events.
b
Risk factors not associated to events.