Table 2.

ABCD Rule for Dose-Reduction of NOACs

	Dabigatran (Either 1 of the Following)	Rivaroxaban	Apixaban (≥2 of the Following)	Edoxaban (≥1 of the Following)
Age (≥80 y)	yes		yes
Body weight (≤60 kg)	yes		yes	yes
Creatinine or CrCl or eGFR	yes (eGFR 30-49 mL/min)	yes (eGFR 30-49 mL/min)	yes (Creatinine ≥1.5 mg/dL)	yes (CrCl 30-50 mL/min)
Drug				yes (Potent P-gp inhibitors)

Reduced doses are 110 mg (dabigatran), 15 mg (rivaroxaban), 2.5 mg (apixaban), and 30 mg (edoxaban)

CrCl = creatinine clearance; eGFR = estimated glomerular filtration rate; P-gp = p-glycoprotein.