Table 1.
Patient Characteristics
| All (N = 656) | ALDH2 Wild (n = 430) | ALDH2∗1/∗2 (n = 199) | ALDH2∗2/∗2 (n = 27) | P Value | |
|---|---|---|---|---|---|
| Age, y | 64 (55-71) | 63 (53-71) | 65 (58-71) | 68 (57-72) | 0.42 |
| Male | 403 (61.4) | 273 (63.5) | 112 (56.3) | 18 (66.7) | 0.20 |
| BMI, kg/m2 | 23.2 (20.9-25.6) | 23.2 (21.1-25.7) | 23.2 (20.8-25.4) | 23.1 (21.8-26.2) | 0.65 |
| BNP, pg/mL | 28.3 (12.9-66.4) | 28.5 (13.6-65.9) | 28.0 (12.6-69.1) | 17.3 (10.4-50.3) | 0.60 |
| EF, % | 63.3 (60.0-66.2) | 63.5 (60.0-66.7) | 62.9 (59.8-65.6) | 64.5 (61.1-67.4) | 0.13 |
| LADs, mm | 35.9 ± 6.3 | 36.3 ± 6.3 | 35.2 ± 6.3 | 34.3 ± 6.5 | 0.03 |
| eGFR, mL/min/1.73 m2 | 72.0 (62.0-85.0) | 72.0 (63.0-85.0) | 70.0 (60.0-84.0) | 65.0 (56.5-81.0) | 0.09 |
| Atrial fibrillation | 392 (59.8) | 261 (60.7) | 122 (61.3) | 9 (33.3) | 0.02 |
| Hypertension | 343 (52.2) | 236 (54.9) | 96 (48.2) | 11 (40.7) | 0.14 |
| Diabetes mellitus | 92 (14.0) | 54 (12.3) | 35 (17.6) | 3 (11.1) | 0.23 |
| Drinking habit | 282 (43.0) | 231 (53.7) | 51 (25.6) | 0 (0) | <0.001 |
| Current smoking | 129 (19.7) | 88 (20.4) | 36 (18.0) | 5 (18.5) | 0.78 |
Values are median (interquartile range), n (%), or mean ± SD.
ALDH2 = aldehyde dehydrogenase; BMI = body mass index; BNP = brain natriuretic peptide; EF = ejection fraction; eGFR = estimated glomerular filtration rate; LAD = left atrial dimension.