Table 1.
Clinical Characteristics of the Participants
| Index Cases |
p Value | Relatives (n = 45) | |||
|---|---|---|---|---|---|
| Overall (N = 124) | Variant – (n = 39) | Variant + (n = 85) | |||
| Age, yrs | 45 ± 14 | 48 ± 12 | 43 ± 14 | 0.038 | 42 ± 20 |
| Male | 77 (62.1) | 25 (64.1) | 52 (61.2) | 0.755 | 21 (46.7) |
| Xanthoma/corneal arcus | 22 (17.7) | 2 (5.1) | 20 (23.5) | 0.013 | 2 (4.4) |
| Personal history of CAD | 88 (71.0) | 27 (69.2) | 61 (71.8) | 0.773 | 8 (30.8) |
| Family history of CAD | 46 (38.0) | 16 (44.4) | 30 (35.3) | 0.878 | 31 (68.9) |
| Statin at admission | 87 (70.2) | 27 (69.2) | 60 (70.6) | 0.343 | 11 (24.4) |
| Definite FH | 48 (38.7) | 11 (28.2) | 37 (43.5) | 0.104 | 9 (20.9) |
| LDL-C, mmol/l | 5.81 ± 2.41 | 5.61 ± 2.39 | 5.90 ± 2.42 | 0.536 | 6.14 ± 1.55 |
| HDL-C, mmol/l | 1.11 ± 0.35 | 1.23 ± 0.33 | 1.05 ± 0.34 | 0.006 | 1.31 ± 0.33 |
| TC, mmol/l | 7.66 ± 2.81 | 7.81 ± 2.98 | 7.59 ± 2.74 | 0.707 | 8.20 ± 1.92 |
| Apo A, g/l | 1.28 ± 0.34 | 1.44 ± 0.33 | 1.20 ± 0.32 | <0.001 | 1.35 ± 0.26 |
| Apo B, g/l | 1.51 ± 0.51 | 1.52 ± 0.39 | 1.50 ± 0.55 | 0.834 | 1.51 ± 0.38 |
| Triglyceride, mmol/l | 1.40 (1.02–1.94) | 1.81 (1.37–2.58) | 1.25 (0.94–1.66) | <0.001 | 1.30 (1.01–2.03) |
| Lipoprotein (a), mg/dl | 31.65 (16.26–67.28) | 23.84 (8.17–45.93) | 35.74 (17.31–73.33) | 0.106 | 25.00 (10.51–44.34) |
Values are mean ± SD, n (%), or median (25th–75th percentile).
apo = apolipoprotein; CAD = coronary artery disease; FH = familial hypercholesterolemia; HDL-C = high-density lipoprotein-cholesterol; LDL-C = low-density lipoprotein-cholesterol; TC = total cholesterol.