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. 2022 Nov 2;22:1124. doi: 10.1186/s12885-022-10229-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Functional Study of B7-H3 CAR-T cells in vitro. A The cytotoxicity of B7-H3 targeted CAR-T cells against solid tumor cell lines was analyzed by RTCA assay. The red arrow represents the time point of effector cell addition. B Comparison of killing rates under different E:T ratios on tumor cells. C Levels of IFNγ and TNFα released by B7-H3 CAR-T cells analyzed by ELISA after incubated with cells for 20 h. D Situation of effector cells and target cells (U-2 OS) displayed by optical microscopy. mean ± SEM; ns not significant P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001