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. 2022 Nov 2;19:18. doi: 10.1186/s12950-022-00315-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The potential targets and pathways between COPD and HUA. A The Venn diagram showing the shared genes between COPD and HUA. B The protein interaction network of 27 common genes. C The bar plot showing the GO enrichment of core common genes including CC, MP and CM. D The bar rplot showing the cellular component terms in GO enrichment. E The bubble plot showing the KEGG enrichment of common genes. F The hub-genes among the core 27 shared genes. G The Venn diagram showing the shared genes between AECOPD and HUA. H The hub-genes among the common 9 genes. Abbreviation: CC, cell component; BP, biological process; MF, molecular function; AECOPD, Acute Exacerbation of Chronic Obstructive Pulmonary Disease; HUA, hyperuricemia; COPD, chronic obstruction pulmonary disease