Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 2;19:18. doi: 10.1186/s12950-022-00315-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 4 — Identification of plasma, sputum and bronchoalveolar lavage fluid (BALF) derived EVs from included COPD patients. A Morphology of extracellular vesicles by electron microscope and transmission electron microscope. B Exosome nanoparticle tracking analysis. The mean size of EVs in sputum is 124.4 nm; EVs in BALF is 142.1 nm; EVs in serum is 124.1 nm. C Identification of characteristic marker including TSG101 and CD63 by western blot. D Level of IL-6, IL-8, Elane, Antitrypsin and MUC1 in extracellular vesicles derived from sputum, BALF and plasma of COPD patients examined by western blot. E Heatmap indicating the results of mRNA expression of significant difference genes between two groups (HBE treated CSE and subsequent EVs isolated from patients with or without HUA). F-G KEGG enrichment (F) and GO enrichment (G) analysis of these significant differentially expressed genes. Abbreviation: BALF, bronchoalveolar lavage fluid; TSG101, tumor susceptibility gene101; CD63, lysosomal membrane-associated glycoprotein 3; MUC1, mucin 1; EVs, extracellular vesicles; COPD, chronic obstruction pulmonary disease