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. 2022 Nov 2;23:946. doi: 10.1186/s12891-022-05853-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Nutritional deficiency can inhibit increase the expression of ATF4 and inhibit PKM2 in NP cells

(A) The NP cell proliferation status detected by CCK8 under the different condition of nutritional deficiency (B)The expression level of ATF4 and PKM2 detected by western blot under the different condition of nutritional deficiency. (Group A, B, C, D denotes the media contain 10%, 5%, 1% and 0% FBS, respectively) (C) The quantity analysis of expression level of ATF4 and PKM2 as showed in B (D) The expression level of ATF4 and PKM2 detected by western blot under serum free condition with different time (E) The quantity analysis of expression level of ATF4 and PKM2 as showed in D. Data are mean ± s.d. The percentage calculation in each tissue were measured at least 1000 cells each sample. Statistical significance was determined by one-way ANOVA and Student’s t-test. **, ##, △△ P < .001