Table 1.
Small-molecule inhibitors targeting glycolytic metabolism in CRC
| Compound | Target | Combined therapy | Outcomes | Reference |
|---|---|---|---|---|
| BAY-876 | GLUT1 | NA | Inhibit proliferation | [258] |
| WZB117 | GLUT1 | 5-Fu | Reduce 5-Fu resistance | [261] |
| 2-DG | HK | 5-Fu/Oxaliplatin | Increase chemosensitivity, inhibit migration | [265] |
| Gossypol | LDHA | 5-Fu | Increase chemosensitivity, inhibit tumor growth in vivo and vitro | [270–272] |
| Dichloroacetate | PDK | 5-Fu/Oxaliplatin | Increase chemosensitivity, inhibit tumor growth in vivo and vitro | [273–275] |
| AZD3965 | MCT1 | NA | Inhibit growth and glycolysis | [276] |
| SLC-0111 | CAIX | 5-FU | Increase chemosensitivity, inhibit tumor growth | [277, 278] |