Table 1.
Clinical and histopathological features of convalescent COVID-19 subjects and comparators.
| Sub. | Sex | Patient type | Histopathological Diagnosis | Focus Scorea | Fibrosis/Atrophy | Other Features | Oral Symptoms | Oral Signs | Ocular symptoms | Ocular Signs | COVID-19 Severity | Biopsy Post COVID-19 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1d | F | Conv. | FLS with Mild Chronic Sialadenitis | 0b | N | N | N/A | N | NA | Mild | 8 | |
| 2d | F | Conv. | FLS with Mild Chronic Sialadenitis | 1 | Y | Duct injury and dilatation | Y | Y | N/A | N/A | Mild | 0c |
| FLS with Mild-to- Moderate Chronic Sialadenitis | 2 | Y | GC | Y | N | N/A | N/A | 6 | ||||
| 3d | M | Conv. | FLS with Mild Chronic Sialadenitis | 0b | Y | Inflamm. infiltrating acini | Y | N/A | N/A | N/A | Mild-to-Moderate | 13 |
| 4e | F | HV | Mild Chronic Sialadenitis | 0 | N | N | N | N | Y | Mild-to-Moderate | 21 | |
| 5e | M | HV | FLS with Mild-to-Moderate Chronic Sialadenitis | 2 | N | GC, granuloma | N | N | N | N | Asymp. | UNK |
| 6e | M | HV | FLS with Mild Chronic Sialadenitis | 0b | N | Perivascular infiltrates | Y | N | N | Y | Mild-to-Moderate | 7 |
| SjDe | F | SjD | FLS with Mild-to- Moderate Chronic Sialadenitis | 2 | Y | Y | Y | Y | Y | |||
| CTLe | F | HV | Normal Histology | 0 | N | N | N | N | N |
The focus score (FS) is the number of inflammatory infiltrates of at least 50 cells present in 4 mm2 of salivary gland area.
The subjects has focal lymphocytic sialadenitis (FLS) but with less than 1 per 4 mm2 of tissue. P2 has 8 foci per 37 mm2 of tissue (FS: 0.9) and P6 has 5 foci per 25 mm2 (FS: 0.8), and thus are borderline. Subject 3 has 4 foci per ~47 mm2 (FS: 0.3).
The patient had a biopsy 5 days after first symptom of COVID-19. Patient 2 clinical D5 case was reported in Huang, Perez, et al., Nature Med. 2021 (ref).
The subjects were enrolled on 20-D-0094 and biopsied as convalescent subjects (Subjects 1–3).
The subjects were enrolled on 15-D-0051 as either affected subjects (“SjD”) or healthy volunteers (HV) (Subjects 4–6 and Ex: HV).
Age range of subjects and comparators was 19–42 years.
Abbreviations: F, female; M, male; Conv., convalescent; N, no; Y, yes; FLS, focal lymphocytic sialadenitis; GC, germinal center; UNK, unknown; SjD, Sjögren’s Disease; HV, healthy volunteer; CTL, control gland from healthy volunteer.