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[Preprint]. 2023 Apr 24:2022.10.21.513237. Originally published 2022 Oct 24. [Version 2] doi: 10.1101/2022.10.21.513237

Figure 3: Designed antibodies improve pseudoviral neutralization over COV2-2130.

Figure 3:

The parental COV2-2130 antibody (orange circles), cross-reactive positive control antibody S2K146 (magenta squares), negative control antibody DENV-2D22 (gray x), and down-selected computationally designed antibodies were assayed by neutralization with lentiviruses pseudotyped with spike variants of WA1/2020 D614G (A), Omicron BA.1 (B), BA.1.1 (C), BA.2 (D), and BA.4 (E). (F) Symbols for each antibody are indicated in the legend. (G) IC50 values and 95% confidence intervals. “>” indicates a value > 10,000; NC indicates positive hill slope or failure to converge. Symbols indicate the mean and standard deviation of two technical replicates; curves are 4-parameter logistic regression models fit using GraphPad Prism.