Table 2.

Objectives considered for Pareto selection of candidate sequences, with associated units and weights.

Objective (gi)	Units	Weight (wi)
Rosetta Flex ddG, L452R (Delta)	Rosetta Energy Units (REU)	−1.0
Rosetta Flex ddG, BA.1	REU	−1.0
Rosetta Flex ddG, BA.1.1	REU	−1.0
Atomistic MD ddG BA.1	KCal/Mol	−1.5
SFE ddG, BA.1	REU	−1.5
SFE ddG, BA.1.1	REU	−1.5
FoldX ddG, L452R (Delta)	KCal/Mol	−0.5
FoldX ddG, BA.1	KCal/Mol	−0.5
FoldX ddG, BA.1.1	KCal/Mol	−0.5
FEP stability ddG	KCal/Mol	−0.5
AbBERT score	Arbitrary Units (AU)	2.0