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Mechanism and major binding sites of nirmatrelvir for suppressing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro). Nirmatrelvir forms a reversible thioimidate adduct by the binding of its nitrile carbon to the Mpro Cys145 to suppress Mpro. (Reprint from Ref. [20] with permission).
