Table 4.
Multivariate logistic regression analysis to adjust ORs of genetic models in MMP SNPs for potential confounding factors
| SNP | Genetic model | Confounding factor | OR | 95% CI | P value |
|---|---|---|---|---|---|
| MMP9 rs3918242 | TT + CT vs. CC | Age | 1.48 | (1.11–2.84) | 0.0254 |
| Sex | 1.35 | (1.05–3.04) | 0.0483 | ||
| Fever | 1.59 | (1.12–2.55) | 0.0215 | ||
| Cough | 1.50 | (1.20–2.81) | 0.0134 | ||
| Dyspnea | 1.27 | (1.22–3.10) | 0.0312 | ||
| Sputum | 1.39 | (1.07–2.89) | 0.0380 | ||
| Vomiting/diarrhea | 1.42 | (1.21–2.77) | 0.0244 | ||
| Delirium | 1.55 | (1.30-3.00) | 0.0401 | ||
| Encephalitis | 1.39 | (1.19–3.13) | 0.0219 | ||
| Headache | 1.70 | (1.09–2.17) | 0.0304 | ||
| CC (Reference) | 1.00 | - | - | ||
| MMP3 rs3025058 | GG vs. CC | Age | 6.28 | (1.25–25.88) | 0.0014 |
| Sex | 6.14 | (3.11–20.40) | 0.0054 | ||
| Fever | 5.45 | (2.49–28.02) | 0.0188 | ||
| Cough | 6.11 | (2.87–26.43) | 0.0057 | ||
| Dyspnea | 7.05 | (3.04–29.14) | 0.0084 | ||
| Sputum | 6.28 | (2.65–26.69) | 0.0067 | ||
| Vomiting/diarrhea | 6.70 | (2.99–27.03) | 0.0040 | ||
| Delirium | 7.26 | (2.87–30.14) | 0.0091 | ||
| Encephalitis | 6.81 | (2.14–23.80) | 0.0049 | ||
| Headache | 6.37 | (2.16–26.92) | 0.0304 | ||
| GG vs. GC + CC | Age | 7.14 | (1.88–24.39) | 0.0015 | |
| Sex | 6.36 | (2.16–29.02) | 0.0305 | ||
| Fever | 6.98 | (2.49–24.27) | 0.0058 | ||
| Cough | 6.41 | (2.09–28.65) | 0.0091 | ||
| Dyspnea | 7.25 | (2.14–27.98) | 0.0037 | ||
| Sputum | 7.30 | (2.05–30.07) | 0.0024 | ||
| Vomiting/diarrhea | 7.07 | (2.19–29.60) | 0.0039 | ||
| Delirium | 7.10 | (2.14–28.19) | 0.0109 | ||
| Encephalitis | 6.57 | (2.44–23.01) | 0.0076 | ||
| Headache | 6.51 | (2.10-22.89) | 0.0083 | ||
| CC (Reference) | 1.00 | - | - |
MMP, Matrix metalloproteinase; OR, Odds ratio; CI, Confidence interval