Table 2.
Frequency of side effects reported at treatment week 4 with a high-cannabidiol (CBD) study product for anxiety.
| Side Effects | Patients (n = 14) n (%) |
|---|---|
| Sleep | |
| Sleepiness/fatigue | 3 (21.4%) |
| Sleeping more | 2 (14.3%) |
| Sleeping less | 1 (7.1%) |
| Energy | |
| Increased energy* | 3 (21.4%) |
| More talkative | 2 (14.3%) |
| Less talkative | 1 (7.1%) |
| Physiologic | |
| Dry mouth | 3 (21.4%) |
| Cognitive | |
| Cognitive cloudiness | 2 (14.3%) |
| Memory problems | 1 (7.1%) |
| Difficulty concentrating | 1 (7.1%) |
| Gastrointestinal | |
| Decreased appetite | 1 (7.1%) |
| Increased appetite* | 1 (7.1%) |
| Weight gain | 1 (7.1%) |
| Constipation | 1 (7.1%) |
| Anxiety | |
| Anxiety | 1 (7.1%) |
| Alcohol use | |
| Decreased alcohol use | 1 (7.1%) |
| Libido | |
| Increased libido | 1 (7.1%) |
| Other (write-in) | |
| Acid reflux* | 1 (7.1%) |
Unless otherwise noted, all side effects were rated as mild; no side effects were rated as severe.
*One person rated this side effect as moderate.
The following side effects were also queried, but were not endorsed by any patient:
Energy: lassitude, decreased energy, couch lock.
Physiologic: muscle twitching, dizziness, itchy skin, sweating, headache, urinary retention
Cognitive: feeling altered.
Gastrointestinal: nausea, abdominal discomfort, diarrhea, weight loss.
Anxiety: panic.
Alcohol Use: increased alcohol use.
Libido: decreased libido.
Cardiovascular/Respiratory: heart racing/palpitations, respiratory symptoms.
Mood/Psychiatric: apathy, depression, mania, racing thoughts, paranoia.