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. 2022 Nov 2;54(11):1862–1871. doi: 10.1038/s12276-022-00871-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Genome-wide iSAFE values were obtained using KOVA 2, Japanese, Chinese, and European cohorts. Gene loci indicated with triangles are separately displayed in b. b Regional plots of the iSAFE values from the same set of ethnic cohorts, as marked in a. c The KOVA iSAFE scores of selected tag SNPs in the ADH1A/1B locus (top) and their haplotype frequencies by population (bottom). Bar plots denote the MAF of designated SNPs in each population, and SNPs with asterisks denote major markers for haplotype identification used in Han et al., 2007⁴².