Table 2.

Hypometabolic clusters identified from the voxel-based group comparisons between post-COVID-19 condition outpatients and healthy controls (p-voxel < 0.005, uncorrected, p-cluster < 0.05 FWE corrected)

	Localization	Cluster volume (mm3)	x	y	z	T-voxel max
Cluster 1*	Right frontal: superior, medium and inferior, orbital superior, opercular, precentral, paracentral, supplementary motor area Right temporal: superior, medium and inferior, polar superior and medium, Heschl’s gyrus, fusiform, hippocampus, parahippocampus Right parietal: paracentral and post central, supramarginal, angular, inferior, cingulum posterior, precuneus Right occipital: inferior, lingual Right insula Right thalamus, putamen, and pallidum Left hemisphere: fusiform, hippocampus, parahippocampus, lingual, calcarine, cingulum posterior, cingulum medium, precuneus, cuneus, thalamus	137 239	− 18	− 46	− 3	5.79
Cluster 2*	Right temporal: medium Right occipital: medium and inferior	6 272	53	− 79	− 11	5.58
Cluster 3	Left temporal: superior, Heschel gyrus Left insula Left caudate, putamen, pallidum, and thalamus	5 754	− 22	− 12	4	3.48

*Still significant at p value < 0.05 corrected for voxel using the FWE method