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. 2022 Nov 2;7:136. doi: 10.1038/s41541-022-00549-y

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© The Author(s) 2022, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a SARS-CoV-2 saRNA vaccine schematic. b RNA/nanostructured lipid carrier (NLC) vaccine formulation. Design by Cassandra Baden. c Size distribution of NLC formulation particles alone (black) and saRNA/NLC complex (pink) showing mean and standard deviation of n = 3 replicate measurements for each sample. d SARS-CoV-2 saRNA complexed to the outside of the NLC particles is full-length intact saRNA that is protected by the NLC complexation from RNase degradation. Lanes were derived from the same gel and re-arranged (see Supplementary Fig. 7). e Western blot showing SARS-CoV-2 spike (S) protein expression in saRNA/NLC vaccine-transfected HEK-293 cells. Blot was derived from the same experiment and processed in parallel. See Supplementary Fig. 7 for the original unprocessed blot image.