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. 2022 Nov 2;7:136. doi: 10.1038/s41541-022-00549-y

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© The Author(s) 2022, corrected publication 2022

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Fig. 2 — a Serum SARS-CoV-2 spike protein-binding IgG. Horizontal lines show geometric mean. b Serum SARS-CoV-2 neutralizing antibodies against the original Wuhan strain. Results show geometric mean and 95% confidence interval. c Serum SARS-CoV-2 spike protein-binding IgG1 versus IgG2a indicates a strong Th1-biased response. Horizontal lines show median. The vector control represents mice injected with 10 μg of NLC-complexed saRNA expressing the non-immunogenic secreted embryonic alkaline phosphatase gene. n = 10 mice per group.