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. 2022 Nov 2;7:136. doi: 10.1038/s41541-022-00549-y

Fig. 3. Immunogenicity of SARS-CoV-2 D614G, D614G-2P, and D614G-2P-3Q saRNA/NLC vaccines after 10 µg prime or prime-boost immunization of C57BL/6J mice.

Fig. 3

a Serum SARS-CoV-2 spike protein-binding IgG. Horizontal lines show geometric mean. b–d Serum SARS-CoV-2 neutralizing antibody titers against the original Wuhan, Alpha (B.1.1.7), and Beta (B.1.351) pseudovirus variants. The vector control represents mice injected with 10 μg of NLC-complexed saRNA expressing the non-immunogenic secreted embryonic alkaline phosphatase gene. Results show geometric mean and geometric standard deviation. n = 10 mice per group.