Table 1.
List of the 44 confirmed hit molecules retrieved from the HTS campaign as potential N-protein ligands.
| Compound | IC50 (µM) | + Error* | − Error* |
|---|---|---|---|
| Chebulinic acid | 0.2 | 0.0 | 0.0 |
| L-Chicoric acid | 0.5 | 0.1 | 0.1 |
| Punicalagin | 0.7 | 0.1 | 0.0 |
| Punicalin | 0.7 | 0.1 | 0.1 |
| Suramin | 0.8 | 0.1 | 0.1 |
| Tannic acid | 1.4 | 0.2 | 0.2 |
| Chlorophyllin B | 2.2 | 0.2 | 0.3 |
| Corilagin | 2.4 | 0.5 | 0.4 |
| 4,5-Dicaffeoylquinic acid | 3.0 | 0.5 | 0.3 |
| Methyl Blue | 4.2 | 0.3 | 0.3 |
| Embelin | 5.0 | 0.9 | 0.7 |
| Linaclotide | 5.5 | 0.6 | 0.5 |
| Isochlorogenic acid A | 5.5 | 1.0 | 0.8 |
| Sennoside A | 5.7 | 0.8 | 0.7 |
| Lusutrombopag | 6.0 | 0.6 | 0.5 |
| (R)-(-)-Gossypol acetic acid | 6.4 | 0.4 | 0.4 |
| Idasanutlin | 6.5 | 0.7 | 0.6 |
| Sulfamerazine | 6.5 | 0.9 | 0.8 |
| Eltrombopag | 7.1 | 0.9 | 0.9 |
| Gossypol acetic acid | 7.1 | 0.5 | 0.4 |
| IOWH-032 | 7.7 | 0.9 | 0.8 |
| Anacardic Acid | 7.7 | 0.9 | 0.7 |
| Pranlukast (hemihydrate) | 7.8 | 1.1 | 1.0 |
| Eltrombopag | 8.1 | 1.0 | 0.9 |
| Succinobucol | 8.1 | 0.6 | 0.5 |
| RNPA1000 | 9.6 | 1.8 | 1.4 |
| TMC647055 | 10.0 | 1.2 | 1.0 |
| Montelukast | 10.3 | 1.1 | 1.0 |
| Micafungin | 10.4 | 0.9 | 0.8 |
| Zafirlukast | 10.4 | 1.6 | 1.4 |
| Resazurin | 10.5 | 1.7 | 1.4 |
| Verteporfin | 10.8 | 3.4 | 2.6 |
| Chlorophyllin A | 10.8 | 1.2 | 1.0 |
| Surfactin | 11.1 | 1.5 | 1.3 |
| Pentagalloylglucose | 11.6 | 1.9 | 1.7 |
| Hexachlorophene | 13.0 | 1.6 | 1.3 |
| Ertapenem sodium | 13.8 | 1.4 | 1.3 |
| MK 0893 | 14.4 | 1.1 | 0,9 |
| Butenafine | 15.7 | 1.3 | 1.2 |
| Oleic acid | 15.7 | 0.9 | 0.8 |
| Simeprevir | 16.5 | 0.9 | 0.9 |
| Sofalcone | 18.5 | 1.6 | 1.5 |
| Bithionol | 23.0 | 5.6 | 4.6 |
| Gallic acid | 23.3 | 3.3 | 2.9 |
Compounds are ranked by their IC50 values for blocking the N protein-RNA1 interaction. Phenyl propanoids with dicaffeoyl motif are highlighted in bold.
*Reported errors are deviation from mean value for upper (+ Error) and lower (− Error) limits of 95% confidence intervals.