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. 2022 Nov 1;54(11):1850–1861. doi: 10.1038/s12276-022-00870-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The ADCC activities of trastuzumab-YTE a, trastuzumab-LS b, and trastuzumab-PFc29 c were compared with that of trastuzumab. Luminescence signals resulting from trastuzumab-Fc variants engaging with target cells (SKBR-3) and effector cells (FcRIIIa-158V-expressing engineered Jurkat) were measured. d–f The CDC activities of rituximab-YTE d, rituximab-LS e, and rituximab-PFc29 f were analyzed using normal human complements and Raji cells as target cells. Rituximab-containing wild-type Fc was used as the control.