FIG. 2.

Antibody responses of 15 groups of five mice each immunized i.n. (IN) or i.p. (IP) with meningococcal NOMV. Seven groups received the following doses of NOMV vaccine i.n., under anesthesia, in a volume of 25 μl, at days 0 and 28: 0.03, 0.10, 0.30, 1.0, 3.0, 10, and 20 μg. Seven additional groups received the following doses of NOMV vaccine i.p. at days 0 and 28: 0.01, 0.03, 0.10, 0.30, 1.0, 3.0, and 10 μg. Mice were bled at days 28 and 42. One group of five mice served as negative controls; these animals were sham immunized either i.n. or i.p. with saline. Median, minimum, and maximum values are represented by the vertical bars.