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. 2022 Nov 2;57(Suppl 1):100–416. doi: 10.1038/s41409-022-01798-0
Characteristics n (%)
Recipient/donor age; median (range) 50 (16-73)/39 (14-75)
Recipient/donor male sex 85 (56)/85 (56)
Male receptor/Female donor 37 (24)
Hematological disease
 AML / MDS 63 (42)/19 (13)
 HL / NHL 22 (15)/24 (16)
 ALL 9 (6)
 CMML 5 (3)
 Others 4 (5)
 Previous treatments ≥2 93 (61)
 Previous autologous transplantation 35 (23)
 Previous allogenic transplantation 13 (8)
 Disease risk index ≥ high and very high 27 (18)
 Sorror, n (%) >3 44 (29)
Conditioning
 Myeloablative 35 (23)
 Flu (150mg/m2) + Bu (9,6mg/Kg) + Thio (10mg/Kg) 29 (19)
 Flu(150mg/m2)+Bu (9,6 mg/kg) + Cy(29mg/kg) 6 (4)
 Reduced intensity 112 (73)
 Flu (150 mg/m2) + Bu (3,2 ó 6,4mg/Kg) + Cy (29mg/Kg) 99 (65)
 Flu (150 mg/m2) + TBI (2Gy) + Cy (29 mg/kg) 5 (3)
 Flu(150mg/m2)+Bu(6,4mg/kg)+Thio(10mg/kg) 8 (5)
 Sequential 5 (4)
GVHD prophylaxis
 Tacro + MMF + Cy 148 (98)
 CsA + MMF + Cy 3 (2)
 CD34 + x108 infused dose, median (range) 6,26 (2.59-9,34)
 Graft source: Peripheral blood 148 (98)
 Median follow up months, n (range) 35 (9-87)
 Overall Survival (OS) 2 years 66%
 PFS 2 years 60%
 NRM day 100 / 1 year 14% / 24%
 Cumulative incidence of aGVHD II-IV day 180 57%
 Cumulative incidence of aGVHD III-IV day 180 13%
 GRFS (Graft versus host-free relapse-free survival) 2 years 49%