Recipient/donor age; median (range) |
50 (16-73)/39 (14-75) |
Recipient/donor male sex |
85 (56)/85 (56) |
Male receptor/Female donor |
37 (24) |
Hematological disease |
AML / MDS |
63 (42)/19 (13) |
HL / NHL |
22 (15)/24 (16) |
ALL |
9 (6) |
CMML |
5 (3) |
Others |
4 (5) |
Previous treatments ≥2 |
93 (61) |
Previous autologous transplantation |
35 (23) |
Previous allogenic transplantation |
13 (8) |
Disease risk index ≥ high and very high |
27 (18) |
Sorror, n (%) >3 |
44 (29) |
Conditioning |
Myeloablative |
35 (23) |
Flu (150mg/m2) + Bu (9,6mg/Kg) + Thio (10mg/Kg) |
29 (19) |
Flu(150mg/m2)+Bu (9,6 mg/kg) + Cy(29mg/kg) |
6 (4) |
Reduced intensity |
112 (73) |
Flu (150 mg/m2) + Bu (3,2 ó 6,4mg/Kg) + Cy (29mg/Kg) |
99 (65) |
Flu (150 mg/m2) + TBI (2Gy) + Cy (29 mg/kg) |
5 (3) |
Flu(150mg/m2)+Bu(6,4mg/kg)+Thio(10mg/kg) |
8 (5) |
Sequential |
5 (4) |
GVHD prophylaxis |
Tacro + MMF + Cy |
148 (98) |
CsA + MMF + Cy |
3 (2) |
CD34 + x108 infused dose, median (range) |
6,26 (2.59-9,34) |
Graft source: Peripheral blood |
148 (98) |
Median follow up months, n (range) |
35 (9-87) |
Overall Survival (OS) 2 years |
66% |
PFS 2 years |
60% |
NRM day 100 / 1 year |
14% / 24% |
Cumulative incidence of aGVHD II-IV day 180 |
57% |
Cumulative incidence of aGVHD III-IV day 180 |
13% |
GRFS (Graft versus host-free relapse-free survival) 2 years |
49% |