Parameters (n = 43) | Number (%) or median (min-max) | ||
Age (year) | 56 | (25-73) | |
Gender (Female/Male) | 14/29 | ||
Disease | Multiple Myeloma | 26 | (60,4) |
Hodgkin Lymphoma | 4 | (9,4) | |
Non-Hodgkin Lymphoma | 13 | (30,2) | |
Pre-transplant chemotherapy line | ≤3 | 37 | (86) |
>3 | 6 | (14) | |
Pre-transplant response to therapy | Complete remission | 35 | (81,3) |
Partial remission | 7 | (16,2) | |
Stabil disease | 1 | (2,5) | |
CMV status pre-transplant | CMV IgG positive | 43 | (100) |
CMV IgM positive | 0 | (0) | |
Engraftment time (day) | Neutrophil count | 12 | (9-51) |
>500/mm3 | 14 | (8-51) | |
CMV reactivation in the study cohort | Platelet count > 20000/mm3 | 43 | (11,9) |
Yes | 317 | (88,1) | |
No | |||
Reason for checking CMV level | Prolonged fever | 14 | (32,5) |
Diarrhea | 5 | (11,6) | |
Pneumonia | 9 | (20,9) | |
Liver enzyme elevation | 6 | (14,1) | |
Cytopenia | 9 | (20,9) | |
Time to reactivation (day) | 39 | (8-1825) | |
CMV antigenemia (IU/mL) | Moment of diagnosis | 467 | (27-36385) |
Peak level | 482 | (27-78987) | |
Anti-CMV therapy | Ganciclovir | 12 | (57,1) |
Valganciclovir | 9 | (42,9) | |
Treatment-related toxicity | Neutropenia | 2 | (20) |
Pancytopenia | 2 | (20) | |
Hypomagnesemia | 3 | (30) | |
Hypocalcemia | 2 | (20) | |
Acute kidney failure | 1 | (10) | |
Anti-CMV therapy (day) | Induction therapy | 14 | (7-28) |
Maintenance therapy | 14 | (7-32) | |
Development of CMV disease | Yes | 6 | (13,9) |
No | 37 | (86,1) | |
Mortality (%) | 100-day | 6,9 | |
Overall | 46,5 |