All patients | BuFlu | TreoFlu | p value | |
---|---|---|---|---|
n = 97 | n = 67 | n = 30 | ||
Age, median (min-max) | 57 (19-73) | 54 (19-70) | 62 (26-73) | 0,003 |
Sex, n (%) | 0,107 | |||
Male | 54 (55,7) | 34 (50,7) | 20 (66,7) | |
Female | 43 (44,3) | 33 (49,3) | 10 (33,3) | |
Diagnoses, n (%) | 0,595 | |||
AML | 71 (73,2) | 49 (73,1) | 22 (73,3) | |
MDS | 26 (26,8) | 18 (26,9) | 8 (26,7) | |
Disease status, n (%) | 0,260 | |||
Complete remission | 76 (78,4) | 56 (83,6) | 20 (66,7) | |
Partial remission | 5 (5,2) | 3 (4,5) | 2 (6,7) | |
Progression/refractory | 11 (11,3) | 5 (7,5) | 6 (20) | |
Never treated | 5 (5,2) | 3 (4,5) | 2 (6,7) | |
Prior treatment lines, median (min-max) | 1 (0-4) | 1 (0-4) | 1 (0-3) | 0,102 |
HCT-CI score, n (%) | 0,037 | |||
<3 | 47 (48,5) | 37 (55,2) | 10 (33,3) | |
≥3 | 50 (51,5) | 30 (44,8) | 20 (66,7) | |
Donor, n (%) | 0,566 | |||
HLA-matched sibling | 29 (29,9) | 22 (32,8) | 7 (23,3) | |
HLA-haploidentical sibling | 19 (19,6) | 11 (16,4) | 8 (26,7) | |
HLA-matched unrelated | 44 (45,4) | 30 (44,8) | 14 (46,7) | |
HLA-mismatched unrelated | 5 (5,2) | 4 (6) | 1 (3,3) | |
Stem cell source, n (%) | 0,064 | |||
Bone marrow | 64 (66) | 48 (71,6) | 16 (53,3) | |
Peripheral blood | 33 (34) | 19 (28,4) | 14 (46,7) | |
GvHD prophilaxis, n (%) | 0,243 | |||
Calcineurin inhibitor + MMF/MTX | 67 (69,1) | 46 (68,7) | 21 (70) | |
Cy post + FK + MMF | 20 (20,6) | 12 (17,9) | 8 (26,7) | |
Cy post | 10 (10,3) | 9 (13,4) | 1 (3,3) | |
ATG | 28 (28,9) | 18 (26,9) | 10 (33,3) | 0,338 |