Patient characteristics | TBI-based regimen (n = 28) | Non-TBI based regimen n = 32 | p |
---|---|---|---|
Median age (range), years | 28 (17-49) | 32 (17-48) | 0.31 |
Sex-ratio | 1.33 | 3.6 | 0.08 |
Diagnosis | 0.4 | ||
B-ALL, n (%) | 14 (50%) | 20 (62.5%) | |
T-ALL, n (%) | 12 (43%) | 10 (31.3%) | |
Mixed lineage leukemia, n (%) | 2 (7%) | 2 (6.2%) | |
Median time diagnosis-allo-HSCT (range), months | 6 (2-137) | 7 (3-41) | 0.05 |
Disease status before transplant, n (%) | 0.55 | ||
CR1 | 21 (75%) | 26 (81%) | |
>CR1 | 7 (25%) | 6 (19%) | |
HCT-CI score ≥ 2, n (%) | 8 (28.6%) | 3 (9.4%) | 0.05 |
ABO mismatch, n (%) | 0.55 | ||
Matched | 18 (64.3%) | 17 (53.2%) | |
Major or bidirectional or minor | 10 (35.7%) | 15 (46.8%) | |
Stem cell source, n (%) | 0.35 | ||
Bone marrow | 12(43%) | 10(31%) | |
Peripheral blood stem cell | 26(57%) | 22(69%) | |
GVHD prophylaxis | 0.92 | ||
Cyclosporine and methotrexate +/−ATG | 27(96.4%) | 31(96.9%) | |
Cyclosporine | 1 (3.6%) | 1 (3.1%) |