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. 2022 Oct 31;10(10):e004235. doi: 10.1136/jitc-2021-004235

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Plasma protein analysis and transcriptomic analysis in tumor samples of patients treated with INCAGN01949. (A) Heat map of immune-related plasma protein expression. Log2-fold change in plasma proteins identified to be differentially expressed between C1D1 and either C1D2, C1D7, and/or C2D1 in the cohorts of 70, 200, and 350 mg. (B) Violin plot of biopsy CD8⁺ T cell-related gene expression. Gene expression was analyzed in biopsy samples collected at screening (pretreatment) and on treatment. Statistical significance was calculated using ANOVA F-test; genes depicted reached statistical significance (p<0.05). ANOVA, analysis of variance; C, cycle; D, day; GZMA, granzyme A; GZMB, granzyme B; GZMH, granzyme H; GZMM, granzyme M.