Table 1.
Summary of clustering of short consensus repeats of human complement regulators with each repeat of viral proteins
| Viral proteins | Viral SCR | Most similar repeats in human complement regulatorsa |
|||||
|---|---|---|---|---|---|---|---|
| C4bpα | MCP | DAF | CR1 | CR2 | FH | ||
| VCP, SPICE, IMP | 1 | 1, 5 | 1 | 2 | 1, 8, 15, 22 | NM | 1, 4, 9, 13, 17 |
| 2 | 2 | 2 | 3 | 2, 6, 9, 13, 16, 20, 23, 27 | 4, 8, 11 | 2 | |
| 3 | 3 | 3 | 4 | 3, 5, 7, 10, 12, 14, 17, 19, 21, 24, 26, 28, 29 | 3, 5, 7, 9, 12, 14, 29 | 5, 6 | |
| 4 | 4 | 4 | Noneb | 30 | 2, 6, 10, 13, 15 | 12 | |
a
For each human complement regulator, short consensus repeats that were clustered with each poxvirus SCR 1, 2, 3, and 4 are listed. Only those clusterings between pairs of human and viral SCRs are listed that were observed in both tree inference methods used, the neighbor-joining tree and the strict consensus of 157 parsimony trees.
b
None indicates that neither tree inference method clustered this viral SCR with any repeats from this human complement regulator. The detailed trees showing all clusterings are provided in Fig. 1 and online (see supplementary online material for this report).