Fig. 3. High interaction of Fas (CD95)/FasL (CD95L;CD178) between NK cells and HCC cells through the inhibitory effect of apigenin in HIF-1α expression.

The expression of (A) HIF-1α, (B) Fas and FADD in HCC cells cocultured with NK cells with or without apigenin treatment (50 μM) using Western blot analysis, and (C) the positive population of CD178 on the surface of NK cells cocultured with HCC cells by flow cytometry analysis. Data were compared at *p < 0.05 vs non-treated and **p < 0.05 vs CoCl₂.